Comparing CPAP and BiPAP for Sleep-Disordered Breathing in People with Cervical Spinal Cord Injuries

Technology
General health
Online since 9 June 2025, updated today

About this trial

This pilot trial is enrolling 32 participants with cervical spinal cord injury to test the effect of continuous positive airway pressure (CPAP) versus bilevel positive airway pressure (BiPAP) therapy on sleep. CPAP delivers a constant level of air pressure, while BiPAP provides higher pressure during inhalation and lower pressure during exhalation. Both devices utilize a mask worn over the nose and/or mouth during sleep. If included, participants will be randomly assigned to receive either CPAP or BiPAP therapy for 4 weeks. Final testing of feasibility and sleep quality will be performed after 4 weeks.

Included participants

Gender
All
Age
≥ 19 years
Injury level
C1 - C7
  • Severity (AIS)?
  • AIS-A
    AIS-B
    AIS-C
    Time since injury
    All
    Healthy volunteers
    No
    C1-C7

    What’s involved

    Type

    Technology

    Details

    - Participants will be randomly assigned to receive either continuous positive airway pressure (CPAP) or bilevel positive airway pressure (BiPAP) therapy for 4 weeks, with adjustments made to optimize treatment effectiveness and comfort. - CPAP delivers a constant level of air pressure, while BiPAP provides higher pressure during inhalation and lower pressure during exhalation, both through a mask worn over the nose and/or mouth during sleep. - Final testing of feasibility and sleep quality will be performed after 4 weeks.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Aug 2025
    • Organisation
    • University of British Columbia
    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Aug 2025
    • Organisation
    • University of British Columbia

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more