| NCT07799532 | A Trial Investigating the Efficacy and Safety of NVG-291 in Subjects With Chronic Spinal Cord Injury | NervGen Pharma | | - Age 18 - 75 yrs
- Level C1-C8
AIS - 1 years - 10 years
- NOT have a history of uncontrolled seizures or any seizure within 6 months prior to screening.
- NOT have a body mass index (BMI) \>40 kg/m².
- NOT have a known hypersensitivity to cetirizine, mannitol, trehalose, or polysorbate 80.
- NOT have a clinically significant hepatic disease, alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ≥3 × upper limit of normal, or severe renal impairment (estimated glomerular filtration rate \<30 mL/min/1.73 m²).
- Have documented traumatic spinal cord injury confirmed by historical and/or current magnetic resonance imaging (MRI) or computed tomography (CT).
| Recruiting | 150 | PHASE3 | Drug | Arm/hand function | - 10 Meter Walking Test (10 MWT)
- Adverse Events (AEs)
- Ashworth and Modified Ashworth Scale (MAS)
- Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)
- Spinal Cord Independence Measure (SCIM)
| 12 weeks | 28 September 2026 | 02 September 2026 | 25 | |
| NCT07583576 | Effects of Functional Electrical Stimulation on Spasticity, Quadriceps Muscle Strength and Functional Mobility in Individuals With Paraplegia | Istanbul Medipol University Hospital | | - Age 18 - 65 yrs
- Level T2-S5
AIS C, D- All
- NOT have a cardiac pacemaker or implanted electrical device
| Ended | 0 | NA | Technology | General health | - 10 Meter Walking Test (10 MWT)
- 6-Minute Walk Test (6MWT)
- Ashworth and Modified Ashworth Scale (MAS)
- Spinal Cord Independence Measure (SCIM)
- Timed Up and Go Test (TUG)
| 8 weeks | 10 May 2026 | 13 May 2026 | 0 | |
| NCT07603752 | Implantable Wireless Brain-Machine Interface System for Spinal Cord Injury: Efficacy and Safety Study | Shanghai StairMed Technology Co., Ltd. | | - Age 18 - 65 yrs
- Level C2-C6
AIS A, B, C- ≥ 12 months
- NOT have any metallic objects or devices implanted in the body (e.g., pacemaker, defibrillator, neurostimulator, cochlear implant, electronic devices, drug infusion pumps, etc.)
| Recruiting | 34 | NA | Technology | General health | - Hospital Anxiety and Depression Scale (HADS)
- Lawton Instrumental Activities of Daily Living scale (IADL)
- Patient Health Questionnaire-9 (PHQ-9)
- World Health Organization Quality of Life- BREF (WHOQOL-BREF)
| 6 months | 28 April 2026 | 22 May 2026 | 1 | |
| NCT07594574 | Posterior Minimally Invasive Surgery for Treating Paralytic Scoliosis With Pelvic Obliquity in Children Following Spinal Cord Injury | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | | - Age 6 - 20 yrs
- Level C1-S5
AIS - All
- have a diagnosis of paralytic scoliosis secondary to spinal cord injury during childhood
| Active | 39 | NA | Surgery | General health | | 2 years | 10 August 2024 | 19 May 2026 | 1 | |
| NCT07595497 | Combined TMS-tSCS for Lower Limb Rehabilitation in Chronic Incomplete SCI | National University Hospital, Singapore | | - Age 18 - 65 yrs
- Level C1-L1
AIS C, D- ≥ 12 months
- NOT have implanted electronic devices, such as: Pacemaker, Cochlear implant, Deep brain stimulator, Spinal cord stimulator, Metallic implants in the head or spine
| Recruiting soon | 24 | NA | Rehabilitation | Standing/walking/mobility | - 10 Meter Walking Test (10 MWT)
- 6-Minute Walk Test (6MWT)
- Ashworth and Modified Ashworth Scale (MAS)
- International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Motor Evoked Potentials (MEPs)
- Spinal Cord Independence Measure (SCIM)
- Surface Electromyography (sEMG)
| 20 weeks | 01 January 2027 | 19 May 2026 | 1 | |
| NCT07583277 | Selective Dorsal Rhizotomy as a Cost Effective and Safe Procedure as a Alternative to Intrathecal Baclofen Pump in Patients With Post Traumatic Spasticity | Assiut University | | - Age ≥ 4 yrs
- Level C1-S5
AIS - All
- NOT have undergone a previous intrathecal baclofen pump administration
| Recruiting soon | 32 | NA | Surgery | Spasticity | - Ashworth and Modified Ashworth Scale (MAS)
- Surface Electromyography (sEMG)
| 6 months | 01 June 2026 | 13 May 2026 | 0 | |
