| NCT05756894 | Neurostimulation for Respiratory Function After Spinal Cord Injury | Shirley Ryan AbilityLab | | - Age 18 - 85 yrs
- Level C1-C5
AIS - ≥ 6 months
- have respiratory deficits requiring ventilator use or demonstrate reduced vital capacity (less than 80%)
- Have a caregiver or family member who is trained and willing to operate the ventilator during study visits
- NOT be completely dependent on the support of a diaphragmatic pacer (24 hours per day)
- NOT have history of head injury or stroke
- NOT have history of seizures or epilepsy
- NOT be taking medications that lower seizure threshold
- NOT have metal in the skull including plates, shrapnel, cochlear implants or aneurysm clips
| Recruiting | 10 | NA | Technology | General health | - Motor Evoked Potentials (MEPs)
| 14 weeks | 28 February 2023 | 07 March 2023 | 1 | |
| NCT05693181 | Cord Blood Cells in Patients With Acute SCI | Sklifosovsky Institute of Emergency Care | | - Age 18 - 75 yrs
- Level C1-L5
AIS A, B- ≤ 7 days
- have had decompressive, stabilizing surgery within 5 days post-SCI and prior to the first cell infusion
- NOT have motor function in lower limbs
| | 80 | PHASE1, PHASE2 | Biological/cell based | General health | - Adverse Events (AEs)
- American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Beck Depression Inventory (BDI)
- Short Form 36 (SF-36)
| 12 months | 05 December 2022 | 20 January 2023 | 2 | |
| NCT05637775 | DiSCIoser: Improving Arm Sensorimotor Functions After Spinal Cord Injury Via Brain-Computer Interface Training | I.R.C.C.S. Fondazione Santa Lucia | | - Age 18 - 70 yrs
- Level C1-T1
AIS A, B, C, D- 30 days - 90 days
- be at least 30 days but not more than 90 days after cervical SCI
- NOT have an upper extremity motor score of 40 or greater
| Ended | 30 | NA | Technology | Arm/hand function | - Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)
- International Spinal Cord Injury Pain Classification (ISCIP)
- Motor Evoked Potentials (MEPs)
- Sensory evoked potentials (including mixed and dermatomal, mSSEPs, dSSEPs, contact heat/laser evoked potentials- CHEPS/LEPs)
- Spinal Cord Independence Measure (SCIM)
| 48 hours | 15 November 2022 | 05 December 2022 | 1 | |
| NCT05593237 | Transcranial Magnetic Stimulation for Chronic Neuropathic Pain | University of California, San Francisco | | - Age 18 - 80 yrs
- Level C1-S5
AIS - All
- meet criteria for chronic neuropathic pain
- NOT have implanted device
| Recruiting | 32 | NA | Technology | Mental health and psychosocial factors | - Beck Depression Inventory (BDI)
- Pain Visual Analog Scale (VAS)
| 6 months | 25 April 2022 | 25 October 2022 | 1 | |
| NCT05590065 | Clinical Investigation on the Impact on Safety, Feasibility and Usability of the Design Changes Performed on ABLE Exoskeleton Device With Spinal Cord Injured Patients in a Hospital Setting | ABLE Human Motion S.L. | | - Age 18 - 70 yrs
- Level C5-L5
AIS A, B, C, D- All
| Ended | 5 | NA | Technology | General health | - 10 Meter Walking Test (10 MWT)
- 6-Minute Walk Test (6MWT)
- Quebec User Evaluation of Satisfaction with Assistive Technology (QUEST 2.0)
- Ratings of Perceived Exertion (RPE)
- Spinal Cord Independence Measure (SCIM)
- Timed Up and Go Test (TUG)
- Walking Index for Spinal Cord Injury (WISCI) and WISCI II
| 8 weeks | 19 October 2022 | 21 October 2022 | 1 | |
| NCT05522920 | Spinal Stimulation for Chronic Complete Tetraplegia | NHS Greater Glasgow and Clyde | | - Age ≥ 18 yrs
- Level C3-C7
AIS A- ≥ 1 years
- NOT have any implanted metal devices
- NOT have a history of epilepsy or seizures
- NOT have a cardiovascular disease
| | 12 | NA | Technology | Arm/hand function | - American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Ashworth and Modified Ashworth Scale (MAS)
- Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)
- International Standards to Autonomic Function after SCI (ISAFSCI)
| 38 weeks | 01 August 2022 | 31 August 2022 | 0 | |
