| NCT06847295 | Epidural Electrical Stimulation to Restore Standing and Walking in Patients With Chronic Paralysis Due to Spinal Cord Injury: A Study on Motor Recovery, Spasticity Reduction, and Quality of Life Improvement Through Neuromodulation and Intensive Rehabilitation | University of Sao Paulo General Hospital | | - Age 18 - 50 yrs
- Level C7-T10
AIS A, B- ≥ 6 months
- NOT currently use electronic devices such as baclofen pumps or cardiac pacemakers
| Recruiting | 10 | NA | Technology | Standing/walking/mobility | - Ashworth and Modified Ashworth Scale (MAS)
- Beck Depression Inventory (BDI)
- Berg Balance Scale (BBS)
- Brief Pain Inventory (BPI)
- Fugl-Meyer Assessment (FMA)
- Neurogenic Bladder Symptom Score
- Neurogenic Bowel Dysfunction Score (NBD or NBDS)
- World Health Organization Quality of Life- BREF (WHOQOL-BREF)
| 12 months | 28 January 2022 | 26 February 2025 | 1 | |
| NCT06274021 | Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury | University of Mississippi Medical Center | | - Age ≥ 18 yrs
- Level C1-T11
AIS - ≥ 6 months
- NOT have an implanted active devices
- NOT have passive implants (plates, screws) below the level of injury
- HAVE presence of spasticity in the lower limbs
| Recruiting | 16 | EARLY_PHASE1 | Technology | Spasticity | - Ashworth and Modified Ashworth Scale (MAS)
- Spinal Cord Assessment Tool for Spastic Reflexes (SCATS)
| 5 weeks | 01 March 2024 | 23 February 2024 | 2 | |
| NCT05965700 | NVG-291 in Spinal Cord Injury Subjects | NervGen Pharma | | - Age 18 - 75 yrs
- Level C1-C8
AIS B, C, D- 20 days - 90 days
- NOT have a spinal cord injury due to gunshot wound or penetrating injury
- NOT have an implanted device in the brain or spinal cord
- NOT have an implanted pacemaker
- be able to volitionally initiate at least one step (without body weight support
| Recruiting | 40 | PHASE1, PHASE2 | Drug | Standing/walking/mobility | - 10 Meter Walking Test (10 MWT)
- Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)
- Hand-Held Myometery / Dynamometry
- Motor evoked potential
| 16 weeks | 08 August 2023 | 28 July 2023 | 1 | |
| NCT04288245 | Targeted Plasticity Therapy for Upper Limb Rehabilitation in Spinal Cord Injuries | Baylor Research Institute | | - Age 18 - 64 yrs
- Level C1-C8
AIS B, C, D- ≥ 12 months
| Active | 20 | NA | Technology | Arm/hand function | - Adverse Events (AEs)
- Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)
| 2 years | 15 February 2021 | 28 February 2020 | 1 | |
| NCT06782113 | Safety and Efficacy of the UNILEXA Exoskeleton for Regular Verticalization and Assisted Walking | MEBSTER | | - Age ≥ 18 yrs
- Level T5-T12
AIS A, B- All
| Active | 6 | | | Standing/walking/mobility | - 10 Meter Walking Test (10 MWT)
- Adverse Events (AEs)
- Pain Visual Analog Scale (VAS)
- Quebec User Evaluation of Satisfaction with Assistive Technology (QUEST 2.0)
- Timed Up and Go Test (TUG)
- World Health Organization Quality of Life- BREF (WHOQOL-BREF)
| 14 weeks | 28 November 2024 | 17 January 2025 | 2 | |
| NCT06794242 | Body Representation and Neuropathic Pain in Spinal Cord Injury | Hospices Civils de Lyon | | - Age 18 - 65 yrs
- Level C1-S5
AIS - All
| Recruiting soon | 80 | | | General health | | 2 weeks | 01 April 2025 | 27 January 2025 | 3 | |
